The design method of parameter optimization of nonlinear viscous dampers for dissipation structure was analyzed based on response surface methods. The method included experimental design, finite element analysis, fitting the response surface function and parameter optimization. Taking a reinforced concrete frame structure for an instance, the mathematical model of parameter optimization of viscous dampers for dissipation structure was established by taking the minimum all damping force as objective function and taking the interlayer maximum displacement less than limits as constraints, and then the damper parameters were optimized using the method of nonlinear programming optimization. The results show that the method of parameter optimization of viscous dampers based on response surface method can ensure the structural displacement is less than limit and the construction cost can be reduced.