In order to better understand the seismic performance of the hybrid structure, numerical analysis and shaking table model testing were conducted on a real tall building constructed in Beijing. The nonlinear analytic model of the structure was established with the aid of PERFORM-3D program, and the elastoplastic time-history analysis was performed. From displacement responses and energy dissipation of the entire structure, and deformations and plastic hinge forming condition of components, the response features under different earthquake levels were obtained. Based on the predetermined allowable limits of performance indices, the seismic performance of the structure was evaluated. In the mean time, the numerical analysis results were compared with test results. Both of test results and numerical analysis results indicate that the hybrid structure has good seismic performance.