The cable's motion was modeled by a spring-mass-damper system. The flow field was calculated by RSM combined with the enhanced wall function model and the vibration equation of the cable was solved by the Four Step Runge-Kutta Algorithm, which was written into FLUENT software to be analyzed. It was adopted to analyse the factors influencing vortex-induced vibration of submerged floating tunnel cable, such as mass ratio, damping ratio of the cable and whether to consider streamline movement. The main conclusion included: mass ratio has little influence on the transverse vortex induced vibration amplitude of the cable, but has a big influence on the region of the reduced velocity; damping ratio almost has little influence on the region of the reduced velocity of cable's viv, but has an influence on the cable's vibration amplitude significantly; In the case of low-mass ratio, considered the impact of the cable streamline movement, the transverse vortex-induced vibration amplitude is bigger than not considered the case.