An optimal distribution strategy of the energy dissipation dampers installed in the bottom stories of frame structures was put forward based on dynamic characteristics of base-isolated system. Firstly, the number of stories was defined by calculating the ratio of site characteristic frequency ω and bottom isolation stories natural frequency ωn of energy dissipation structure. Then, with regard to storey drift permissible value, the quantity and installation positions of dampers were defined through several simple calculations. 2 sets of actual strong earthquake records and 1 set of artificial acceleration time-history curve for a 10 stories frame structure were selected to conduct the time-history analysis under frequently and rarely earthquakes by ETABS software and Perform-3D software. The results show that the dynamic characteristics of energy dissipation structure in which the dampers are installed in lower stories are similar to those of base-isolated system.