Polymeric aluminum ferric sulfate (PFAS) was developed by Industrial Grade ferrous sulfate heptahydrate and industrial aluminum sulphate（16% Al2O3）. PFAS was used for printing and dyeing wastewater treatment. The new synthetic Polymeric aluminum ferric sulfate (PFAS) with a unique spatial fold-like structure was discovered by scanning electron microscopy analysis(SEM). The treatment efficiency was evaluated by investigated sludge volume and the reduction of removal rate of COD and turbidity of printing and dyeing wastewater by using single factor. The results show that the removal rate of COD is achieved 83.0%, the removal rate of turbidity is achieved 95.0% and the sludge volume is 52.8 mL when the coagulant dosage is 0.3 g/L and pH is 8.5. Meanwhile, compared with the common coagulant (PFS, PAC and CPAM) in application of printing and dyeing wastewater treatment, the performance on the removal of COD and turbidity of self-make PFAS is better than those of PFS, PAC and CPAM.