To investigate mechanical behavior and seismic behavior of concrete filled steel tubular column node (CFSTCN) in space truss structure, both full-scale test and Finite Element Method (FEM) were employed. The test load was 1.6 times of design load and by incremental step loading. Meanwhile, stress and deformation in CFSTCN were observed to monitor bearing capacity of the node. The results show that steel tubular works in elastic state and a small part of concrete beyond of compressive stress limits; steel tube and concrete adhesive well. The hysteretic energy dissipation capacity and failure mode under cyclic loading were revealed by nonlinear FEM. weakest position and ultimate bearing capacity of the node were obtained from FEM results. The method of combining full-scale test and FEM can well reveal the mechanical behavior and the seismic behavior of the node.