Under the equipotential premise gradient, anode follow-up technical was proposed in the electro-osmosis reinforcement of soft clay. Eight electro-osmosis contrast tests were conducted through the experimental test. Currently, shear strength, displacement, moisture content, pH, conductivity of the soil and other indicators were monitored in the electro-osmosis test. Different electro-osmotic reinforcement effects were analyzed. The results show that: when the anode follow-up is used, the first anode follow-up can get a most significant effect. When the current density is high, arranging the anode follow-up will lead some extent reduce of the effect of the electro-osmosis, while the effect will be promoted when the current density is low. By carrying out the anode follow-up on the cathode region soil, a significant reinforcement effect can be obtained. Anode follow-up can reduce the resistance of the circuit in the anode region and effectively promote the electro-osmosis reinforcement effect.