The earthquake ground motion is non-stationary, and the dynamic reliability of the connected structure with different locations of connector is investigated using pseudo excitation method. The stiffness degradation of Bouc-Wen model is used to simulate the hysteresis of the tower structure, and the nonlinear motion equation of the connected structure is established. The system response for each moment is calculated by mixed precise integration method and the time-history variance of the structure under non-stationary earthquake excitation is obtained. Based on the first passage criterion and Markov assumption, the connected structure reliability are calculated. As a result, the random earthquake response and dynamic reliability of tall double-tower linked with strong connected structure subjected to 8 degree rare earthquakes are analyzed on base of those theories. The results show that the tower displacement responses are non-stationary under the earthquakes, and the change of connector location has a significant impact on the random seismic response and dynamic reliability of the strong connected structure.