The paper introduces the history of the Lester School and Henry Lester Institute of Technical Education. Based on investigation of the site, the paper analyzes its original fire safety and the fire-fighting measures after its transforming into Shanghai Seamen’s Hospital. Then the paper gives the introduction of the reform of the fire-fighting equipment in 2008 and 2014, and raises the existing fire safety hazard. A conclusion is given in the end that though the fire-fighting equipment has been improved, management mechanism should be strengthened as well, and make improvement in the unsafety part of the historical building.