The excessive amount of creeping camber of a simply-supported continuous bridge generated by the over pre-stressed on simply-supported beam, leads to the specific wavy on bridge line. In this paper, a vehicle model on the scale of 1/4 and the half-sine curve are used to simulate the vertical vibration. Then, the Newmark is adopted for calculating the vehicle-bridge interaction. It is found that if the girder camber is not well controlled, not only the safety of bridge construction but also the riding comfort of traveling vehicle will be influenced.