At present, the logistics has become a new economic hot spot as “the third profit source”, which is paid more and more attention by people. With the rapid development of logistics industry, however, there is a common problem to be considered: How to choose logistics center location reasonably Logistics center plays a very important role in the logistics system operation, it is a bridge connects logistics upstream supplier and downstream demand. After having a know of the importance of logistics center, from the vendors, logistics center and the demand side three aspects, aiming at the minimize of the cost, using the mixed integer programming method and the Lingo software for building the logistics center location model and get the results in this article.