Based on the modular modeling framework of ABAQUS program, a simplified mesoscopic model is proposed for masonry structure. The mortar-joint and bond were replaced by a single interface. Shear-compression behaviour and tension behaviour were modeled through the normal and tangential mechanics properties of interface. Sticking mechanics property was adopted to model tensile behavior, and the evolution index α of bonding soft was obtained by equivalent with axial tensile constitutive express. Based on shear-friction theory, shear-compression model was conducted by sticking mechanics and coulomb friction, and through the nonlinear properties of block, the principal compression stress was adopted as the master damage threshold under high axial compression ratio. Simulation of the shear-compression relationship and a brick wall model with shear failure were conducted, and the corresponding failure modes and curves were similar with that theory and test results.