In order to study the variation regularity of mean wind pressure coefficients on gasholder with interference and the transformation of different distance of interference effect, pressure measurements were conducted in wind tunnel on a rigid structural model. Results showed that in the case the interferential gasholder was located in the front, the mean wind pressure coefficients of windward side would dramatically decrease; the interferential gasholder was located in the rear, the mean wind pressure coefficients of lee side would increase; two gasholder were parallel to each other, the mean wind pressure coefficients of windward side would decrease; distance had a influence on the interference effect, interference effect varid with changes of distance; the safety reserve of code values was sufficient on windward and crosswind side but slightly insufficient in windward side.