With the increase of sludge production of wastewater treatment plants, sludge treatment has become one of the hot topics in environmental engineering and environmental geotechnical engineering. Sludge-municipal solid waste(MSW) mixture landfill has been applied abroad. But the current domestic foundational laboratory test result of MSW mixture sample is not much,there is a lack of understanding on its mechanical properties and the appropriate proportion of mixed landfill. Hence domestic sludge-municipal solid waste(MSW) mixture landfill engineering accidents occur frequently. Consolidation compression experiments, three axis consolidated undrained tests and unconfined compressive strength tests are conducted to disscuss the mechanical properties of different mixing ratio of sludge-municipal solid waste(MSW) mixture. At the same time, ANSYS numerical simulation is operated to analyze the slope stability of landfill with different mixing ratio of sludge-municipal solid waste(MSW) mixture. The theoretical support on the appropriate proportion of mixed landfill and stability security of sludge-municipal solid waste mixture landfill is proposed.