Composite walls of RC-autoclaved aerated concrete blocks(CWR) consisting of concrete beam-column grid and aerated concrete blocks was a new type of shear wall, which could be used to strengthen the seismic performance of frame structure. Cyclic reversed loading tests were conducted on frame specimen without CWR, CWR specimens and CWR with outer frame specimens. All the specimens were in the scale of 1:2. The main failure process of the specimens were analyzed. The seismic performances of the frame such as bearing capacity, stiffness and so on before and after being strengthened by CWR were studied. Test results showed that the bearing capacity and lateral stiffness of the strengthened frame structure were increased greatly and about 0.9 times as large as the sum of outer frame structure and CWR that possessed good cooperative work performance. The damage process of the strengthened specimens basically followed the sequence of filling block, reinforced concrete frames and outer frame, and thus could bring the Multi-defense seismic characteristics of the CWR into full play, which indicated that strengthening frame structure with CWR was economic and convenient.