Explicit dynamic finite element program ANSYS/LS-DYNA is adopted. According to the method of fluid-structure interaction, profiled steel-concrete composite slab is simulated under near explosion in different conditions. And the stress form, the dynamic responses and failure process were analysed. Numerical analysis results show that the largest displacement of composite floor slab can be significantly reduced with increasing the thickness of the concrete and improve the strength of the steel plate. The ductility and anti-explosion performance of composite floor slab can be improved. The anti-explosion performance of composite floor slab has less effect by changing reinforced spacing. The reference and basis can be provided for antiknock design of profiled steel-concrete composite slab.