The optimization of the sectional dimensions is studied to make the ratio between performance and steel amount of steel sections become optimal. However, the optimization analysis of lip angle involving the eccentric compression is lack. A technique with the genetic algorithm and formulae for predicting the distortional critical stresses of cold-formed lipped channels subjected to eccentric compression is developed to optimize the angles of lips of channels. The cold-formed lipped channel columns under eccentric compressing have been taken as examples. The genetic algorithm regards the angle of lip and eccentric distance as design parameters. This method not only can decrease workload and aimless calculation but also can obtain accurate optimal angles. The distortional critical stresses of cold-formed lipped channels with different dimensions under simply and clamped supports are obtained, based on the finite strip analyses. The optimal angles of cold-formed channel steel members with different eccentric distances are presented. For designer's convenience of design and application, the degree of 100 is suggested.