Many isolated buildings are built in China after Wenchuan earthquake and Lushan earthquake. Although the isolated structure design has been applied by structure engineering, but the maintenance and management of isolated buildings is inadequate in practical project. Based on field survey and seismic damage investigation, the deficiency of the maintenance and management of the isolated building in mainland China is summarized. Then some experiences from foreign countries are introduced, including Japan and United States. Finally, some suggestions on maintenance and management of isolated buildings are put forward from four aspects, including construction process, acceptance, peacetime inspection and BIM（Building Information Modeling）technology.