Four interior joints with high-strength reinforcement and high-toughness concrete were investigated with low cyclic loading. Joints under different rage of high-toughness concrete and those without were compared in terms of seismic behavior indexes such as bearing capacity, deformability, hysteretic characteristics, stiffness degradation and energy dissipation capacity. The failure patterns, bearing capacity, deformability and seismic behavior of those frame interior joints with high-toughness concrete were improved, and the offective rarge of high-toughness concrete was from core area of joint to the one time adjacent height of beam to improve deformability and stiffness degradation.