Three kinds of mixed solutions of sulfuric acid and nitric acid with the pH value of 1.5, 2.5 and 3.5 were prepared in the laboratory to simulate acid rain environment. The compression properties of brick masonry exposed to acid rain environment was studied. The brick samples, mortar samples and brick-columns were completely immersed in the simulated acid solutions. After being exposed to the solutions for a certain period, compression tests were performed on the three types of the samples. The results showed that with the increase of corrosion time the compressive strength of mortar samples increased firstly and then decreased, whilst the brick samples always decreased. And the lower the pH value of the solutions was, the more the compressive strength of mortar samples and brick samples decreased. With the increase of corrosion time, the ultimate bearing capacity and elastic modulus of brick-columns showed a trend of decrease, and the lower the pH value of the solutions was, the more obvious the trend was. With the increase of corrosion time, the initial stiffness of brick-columns decreased, ultimate failure displacement increased. With the pH value of the solutions declining, the deformation of brick-columns under ultimate load decreased but the brittleness increased. Based on the experimental results, regression formulas were put forward to describe the ascending part of the stress-strain curve and the remaining compressive strength of brick-columns exposed to acid rain environment.