The Kiewitt-8 single-layer reticulated domes were taken as case study. Considering the influence of geometric nonlinearity and temperature on the properties of the material, the dynamic behavior of the single-layer reticulated domes subjected to blast loading in different fire stages was simulated. According to the B-R criterion, the dynamic stability critical overpressure loads of K8 single-layer reticulated domes subjected to blast loading in different fire stages could be determined by the relationship between the peak overpressure of blast and the structural dynamic response. And the influence of parameters such as the rise-span ratio, the roof load and the constraint settings on the dynamic stability of single-layer reticulated domes subjected to blast loading in different fire stages were analyzed. The results show that fires have a great influence on the dynamic stability of the reticulated domes under the impact of explosion, When the maximum temperature of the reticulated dome rods rises to more than 500℃, the anti-explosion ability of the dome greatly decreases. The rise-span ratio, the roof load and the restraint settings have different effects on the anti-blast ability of the reticulated domes in different fire stages.