Microbially Induced Calcite Precipitation (MICP) is a kind of novel biomineralization technique that utilizes natural bacteria isolated from farm land to generate calcite in the pore of soils or rock fracture. This technique could increase both the strength and stability of soil foundation. In this paper, Fujian standard sand was used to process a series of MICP experiments and the mechanical properties were also evaluated by static triaxial test under different confining pressures. It was found that the cohesion of sands improved by 60.1kPa after the MICP treatment. Then, Plaxis was also used to simulate the improvement of soil foundation treated by MICP technique. The improvement of both strength and stability in the embankment of expressway were measured by Shear Strength Reduction Methods. Result shows that MICP technique reinforced the mechanical property of soil foundation, and the slope stability factor was improved from 1.096 to 1.827 after treatment. The stability of expressway embankment improved significantly. Meanwhile, the ultimate slope slip surfaces moved from slope foot to slope surface.