Quasi-static cyclic tests were performed on one SRC column-RC beam frame after exposure to fire and an identical frame at ambient temperature to investigate the post-fire performance of the frame.The load bearing capacity, stiffness degeneration, ductility, and energy dissipation were evaluated, and the cumulative damage and the P-Δ effect were analyzed. Test results showed that after exposure to fire the SRC column-RC beam frame had a lower bearing capacity, less stiffness, lower ductility, increased cumulative damage and a more obvious P-Δ effect compared with its unexposed counterpart. Owing to the existence of core steel in the section of the frame column, after exposure to fire, the hysteresis loops of the SRC column-RC beam frame remained plump, and the load bearing capacity remained relatively high before destruction. Moreover, after exposure to fire, the SRC column-RC beam frame exhibited good energy consumption ability. The plastic limit rotation exceeded 0.04 rad, which could well meet the requirement of China's seismic design code.