Through a quasi-static test of three beam-column joint scale models extracted from the high-rise frame-shear wall structure designed according to the “strong joint” principle in the current national code, the seismic performance of beam-column joints at different positions in frame structures is studied. The test adopts column end loading, considering the influence of the floor slab on the seismic performance of the joint, and analyzes its ductility, stiffness, bearing capacity, energy consumption and other performance indicators. During the test, the development of the cracks was recorded in detail and compared with the mechanical indexes of the components to relate the damage state with the mechanical indexes. The test provides test basis for improving the vulnerability curve and relevant consequence information of the reinforced concrete frame beam-column joints. It is found that the failure modes of the joints at different positions of the frame structure are different. The failure modes of the bottom nodes are shown as bending failure, and the failure is mainly concentrated in the beam ends and column feet toe. No obvious failure in the joint area, while the shear failure occurs in the top joint area. The test results show that the strong joint coefficient and the column end bending moment amplification factor at an extremely high level can completely avoid the damage that needs to be repaired in the beam column joint area, achieve the elasticity of the node, and will not weaken the ductility of the assembly.