This paper takes Yunnan laterite as the research object, takes the wet-dry cycle as the control condition. The indoor unconfined compressive strength test is carried out considering the three influencing factors of wet-dry cycle times, initial moisture content and dry density. The relationship between the unconfined compressive strength of dehumidified laterite under wet-dry cycle and the wet-dry cycle times, initial moisture content and dry density is studied. The results show that the stress-strain relationship curve of the dehumidified laterite presents typical strain-softening characteristics after the wet-dry cycle. Compared with that before the wet-dry cycle, the strain softening characteristics of the stress-strain curve of the laterite after the wet-dry cycle are more obvious, and the unconfined compressive strength increases, and with the increase of the number of wet-dry cycles, the unconfined compressive strength decreases. Under different initial moisture content and dry density, the stress-strain curves of dehumidified laterite are strain softening. With the increase of initial moisture content, the unconfined compressive strength of laterite decreases and the corresponding peak strain increases before the wet-dry cycle, and after the wet-dry cycle, the unconfined compressive strength and the corresponding peak strain of dehumidified laterite increase. With the increase of dry density, the unconfined compressive strength of laterite increases before and after the wet-dry cycle, and the corresponding peak strain also increases.