In view of the difficulty of sludge dewatering and high operating cost in wastewater treatment plants, the effect of NaClO dosage, pH value of the sludge mixture, and the coupling of polymerized ferric sulfate (PFS)/ ferric chloride (FeCl₃) under the optimal dosage of NaClO and the optimum pH value of the sludge mixture on the dewatering performance of sludge were studied in depth, in order to obtain the influence mechanism of oxidation-flocculation conditioning on the dewatering performance of activated sludge. The results showed that when the dosage of NaClO was 40 mg/g DS and pH value of the sludge mixture was 3, the moisture content of mud cake and sludge specific resistance (SRF) after PFS coupled NaClO conditioning were reduced to 85.86% and 4.74×10¹¹ m/kg, respectively. The moisture content and sludge specific resistance of the mud cake after FeCl₃ coupling NaClO conditioning were reduced to 86.36% and 3.93×10¹¹ m/kg, respectively. The relationship of the conditioned sludge floc size D₅₀ is: NaClO+PFS>NaClO+FeCl₃>pH value >raw sludge>NaClO. Obviously, after oxidation-flocculation conditioning, the particle size of the sludge flocs increased significantly, and the organic matter content in the filtrate decreased. Oxidation-flocculation conditioning can significantly reduce SRF and improve the dewatering performance. NaClO coupled PFS and NaClO coupled FeCl₃ are expected to be novel sludge dewatering conditioners with high efficiency, environmental protection and low price.