This paper aims to explore the influence of bedding angle on layered soft rock tunnel under different deformation grades. Based on the large deformation soft rock tunnels along the Jiumian Expressway, the parameters of ubiquitous joint model were determined through rock mechanical test. Based on the numerical simulation, the influence of bedding angle on the stress and deformation of surrounding rock and supporting system of large deformation tunnel in layered soft rock was studied under different soft rock large deformation levels (slight, medium and strong). The results of numerical simulation were verified by field statistical law of bedding angle and large deformation. The results show that: 1) The deformation and stress of surrounding rock and the supporting structure with small angle (0°, 15°) and large angle (90°) of bedding are large, with the increase of large deformation grade, the effect of surrounding rock and support changes caused by bedding angle is more obvious. 2) The deformation of surrounding rock gradually shifts from the arch bottom to the right arch waist with the increase of bedding angle. The surrounding rock deformation mainly occurs at the position where the tunnel contour is tangent to the bedding plane, and the arch bottom and left arch foot are sensitive to bedding angle. 3) The deflection of the initial support stress and the plastic zone of the joint are roughly consistent with the normal direction of the weak plane of bedding. With the increase of bedding angle, the shear plastic zone of joints shifts from vault and arch bottom to left arch foot and right arch shoulder, and finally shifts to the upper and lower position of left and right arch waist. The initial support tension stress is more sensitive to the bedding angle than the compressive stress, vertical joints increase the risk of tensile and shear failure plastic zone transfixion, but the radius of plastic zone in shear failure may decrease. 4) The statistical law of the site is that the large deformation grade of small angle and large angle is higher,strata failure occurred in the waist and shoulder of the arch when the bedding angle is below 60°, the failure of rock strata tends to develop to the spandrel with the increase of bedding angle. Rock failure mainly occurs in the arch waist at large bedding angles.