In order to reduce the crack or damage of the wall caused by the temperature difference between the inner and outer blades when the concrete sandwich slab is used as building envelope, the internal force and deformation of the concrete sandwich slab under the temperature action are studied. The internal and external blade connectors of concrete sandwich slab were homogenized, and the analytical solution of interfacial stress of concrete sandwich slab was deduced, assuming that the internal and external blade only produced bending deformation and the bending curvature of the internal and external blade were different. Thus, the theoretical calculation formula of the position of the most disadvantageous section of internal and external blade of concrete sandwich slab, as well as the internal force and deflection of internal and external blade were obtained, and the theoretical formulas were verified by the finite element software ABAQUS. The results show that the theoretical formula is in good agreement with the finite element analysis results, the internal forces of the most unfavorable section in mid-span of the inner and outer blades of partial composite concrete sandwich slabs have nothing to do with the stiffness of the connectors, and the maximum mid-span deflection increases with the stiffness of the connectors, but the increase is small.