In order to amend the defects of vacuum preloading method, PHD-PVD vacuum preloading combined with electroosmosis to treat engineering waste slurry was proposed. Through six groups of large-scale model tests, the drainage, current intensity and settlement value during consolidation process of engineering waste slurry are monitored, After the test, the soil water content and vane shear strength were measured and combined with mercury intrusion test (MIT) to analyze the soil consolidation effect. The effect of intermittent disconnection of vacuum pump and power supply on the proposed method to strengthen the waste slurry of the project was studied. The test results show that the combination of electroosmosis method can effectively improve the drainage efficiency of PHD-PVD vacuum preloading method in the following stage, and the far end soil has a high degree of consolidation; Intermittent disconnection treatment of vacuum pump and power supply creates new drainage channels in the soil, which to some extent alleviates the siltation near the drainage board, maintains a fast drainage rate in the late test period, and improves the total drainage. MIT results show that the engineering waste slurry treated by intermittent PHD-PVD vacuum preloading combined with electroosmosis method has smaller peak pore diameter and denser soil microstructure.