Because of rapid urbanization and global warming, urban outdoor thermal discomfort and risk of thermal safety increased. In order to find out the physiological parameters changes of human body in outdoor thermal environment, provide a basis for rapid urban thermal environment evaluation, carried out the human thermal response measurement, then analyzed the simulation accuracy and coincidence degree of the two node model, found out that changes of environment which human in and human activity on human physiological parameters. Based on set-point of skin temperature and core temperature, standard human model, temperature of regulation starting, convective heat transfer coefficient, the two-node model was verified and revised, and a new two-node model for predicting outdoor human thermal response was developed.