Sliding bearing is a commonly used type of bearing in cable-stayed bridges, which is also one of the important force transmitting components of bridges. Sliding bearing is often worn during operation, resulting in performance degradation. It is of great significance to analyze the influence of sliding bearing performance changes on the overall mechanical properties of cable-stayed bridges. Based on the finite element model of cable-stayed bridge considering bearing wear, this paper analyzes the influence of sliding bearing wear on the static and dynamic performance of cable-stayed bridge. Taking a cable-stayed bridge as an example, the finite element model of cable-stayed bridge considering bearing wear is established, and the change of the static and dynamic performance of the cable-stayed bridge is analyzed when the sliding bearing is worn. It is shown that sliding bearing wear will increase the bridge stiffness, leading to an increase in frequency, especially longitudinal drift and vertical bending modal, increase the girder end axial force significantly and reduce the cumulative bearing displacement. The bearing cannot adapt to the deformation needs of the girder, resulting in a buildup of internal forces in girder and bearing. This can lead to an increased risk of damage and affect the safe operation of the bridge. This study can provide some guiding suggestions for bearing damage identification and bridge maintenance of cable-stayed bridges.