In this study, Mn-Co@4A catalyst was investigated for catalytic ozonation of coal chemical RO concentrated water. The Mn-Co@4A catalyst was characterized by SEM, EDS, XRF and XRD. The effects of working conditions (initial pH, catalyst filling ratio, ozone dosage, reactor height-diameter ratio) on the catalytic efficiency of ozone catalytic oxidation wastewater were studied. The stability of Mn-Co@4A catalyst was evaluated under optimal conditions, and the mechanism of water treatment was analyzed by UV absorption spectroscopy, three-dimensional fluorescence spectroscopy and free radical quenching experiments. The results show that Mn-Co@4A catalyst has good catalytic performance and stability. Under the conditions of initial pH = 7.64 (raw water), catalyst filling rate of 5%, ozone dosage of 6 mg/L/min, and reaction column height-diameter ratio of 6 : 1, the best COD removal rate of coal chemical RO concentrated water can reach 69.92%. With the increase of oxidation time, the conjugated structural substances, unsaturated ketones and protein-like substances in the RO concentrated water of coal chemical industry were gradually effectively degraded, and .OH and O2.- played the main role in the oxidation of organic matter.