%0 Journal Article %T 超分子材料环糊精与布洛芬包合的热力学测定 %T Mensuration on the thermodynamic property of ibuprofen by inclusion complexation with supramolecular cyclodextrin %A 王建华 %A 冯静 %A WANG,Jian hu %A FENG,Jing %J 重庆大学学报 %J Journal of Chongqing University %@ 1000-582X %V 32 %N 6 %D 2009 %P 653-657 %K 超分子材料;布洛芬;β-环糊精;羟丙基-β-环糊精;稳定常数;热力学参数 %K supramolecular material; ibuprofen; β-cyclodextrin; hydroxypropyl-β-cyclodextrin; stability constant; thermodynamic parameter %X 考察超分子材料环糊精(β-环糊精和羟丙基-β-环糊精) 与布洛芬的包合作用及包合过程热力学参数的变化,探讨包合作用的机理和驱动力。采用相溶解度法研究环糊精对布洛芬的包合作用、增溶作用及包合过程中热力学参数的变化。结果表明,2种环糊精与布洛芬包合反应的吉布斯自由能变化(ΔG)、焓变(ΔH)和熵变(ΔS)均为负值。形成包合物后,布洛芬的溶解度显著增加,羟丙基-β-环糊精对布洛芬的增溶作用强于β-环糊精,稳定常数也高于布洛芬-β-环糊精包合物。2种环糊精在常温常压下可以自发形成包合物,包合过程为放热反应, %X Our objectives are to study the inclusion effects and the thermodynamic parameter changes of the supramolecular materials (β-CD and HP-β-CD) on ibuprofen, and to illustrate the mechanism and driving-power through the inclusion reaction. The phas %R 10.11835/j.issn.1000-582X.2009.06.010 %U http://qks.cqu.edu.cn/cqdxzrcn/home %1 JIS Version 3.0.0