In this paper we explain the method of the measurement of the wormwheel profile error with the three coordinate measuring machine. We first establish the wormwheel theoritical tooth profile equation according to the gear engage principle, then write the computing program and calculate the wormwheel theoritical profile, next analyse and calculate the error of the gage head interference. At last, we work out the measuring program and get the wormwheel profile measured with the three-coordinate measuring machine.