Mannich Reactions of Aromaitic Aldehydes with Aromatic Amines and Aromatic Ketones

Mannich reactions of aromatic aldehydes with aromatic amines amines and aromatic ketones are performed at room temperature or slightly below in the presence of concetrated hydrochloric acid as the catalyst.Forty one new compounds are synthesized with yields of 18.9% to 92%.The effect of substituent in the ring.the amount of hydrochloric acid,reaction temperature and reaction time are systematically examined as well.

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Clc Number:

O625.632 O625.4