The design and optimization of regional sales centers can contribute to the good management of regional sales and the improvement of the efficacy. Its focus is to identify the proper location of physical distribution centers. Based on the GFOLINE Model about the regional sales design,the conditions of the model's application are discussed. By linear programming and grey linear programming model combined with the real practices, two models are established about regional sales, which involves the constraint equations of the optimizing models and some other related practical issues.