Image compression is very important in picture archiving and communication system(PACS). The author studied the statistical distribution of image wavelet subimage coefficients and concluded that the distribution of wavelet subimage coefficients is similar to that of Laplasian distribution. On the other hand, in image reconstruction, the coefficient with different amplitude owns different weight, and different accuracy can be applied to different coefficients according to their different weight. Then, the author has designed a image quantization encoding scheme for PACS. In this scheme, they selected the sample-standard-deviation of coefficients in every subimage as the quantization threshold, and accurately encoded those coefficients with higher weight. Also, this algorithm utilized the visual character of human. The test has proved that the main advantages of this method are the simplicity in computing and predictable encoded coefficients, and a high compression efficiency can obtain too.