In the new environment, product development is the core of product innovation and quickly responsive to the market for the enterprises. The speed and effectiveness of development is the key factor to the success of product development. The design for business is the key technique in achieving the effectiveness of product development. And manufacturing system is the bridge between business and products. The design method of facing business is discussed, and the design flow and content of manufacturing system supporting facing business are pointed out. At the same time, the author also sets forth the construction definition, the construction design and the detailed design of the manufacturing system. So the design flow of manufacturing system facing business is established.