Agglomeration Effects and its evolution lead to the formation and further evolution to multi centers of a city's original center.During the further evolution to multi centers, there exists a rule which is proved to be true by the example of the formation and evolution of The dynamic adjustment of functions between business and trade within centersdrive the formation of a modern city's central business district(CBD).This rule discloses the following facts in planning and policy making of CBD:we must obey the natural rules of city centers' evolution,including the rules of Agglomeration Effects;we must lead CBD to mainly agglomerate business,not agglomerate everything;we can choose the original city center or other place out of the original city center as a CBD's location.