The heterogeneous nature of metallic materials result in residual microstress fields during plastic deformation.The energy stored in the residual microstress fields affects the subsequent plastic deformation. Based on this concept, a nonclassical constitutive model is developed. On the other hand, it is found that there exists difference of dissipative plastic energy between different plastic strain paths. A dissipative plastic energy based hardening parameter is proposed and introduced into the hardening function, which isthen embedded in the non-classical constitutive model. The stress responses of 304 stainless steel subjected to biaxial non-proportional loading are analyzed and the results coincide well with the experimental results.