In order to solve the scheduling problem of frequent distribution of a little goods in one batch between regions in logistics system, We use time slices to manage orders, thus disassembling, combining orders and optimizing the planning to cut the cost. A product-scheduling model in region distribution is presented based on the retailing chain system. A method is presented which spends little cost on logistics plans under constraint conditions (time constraint conditions and space constraint conditions) by using combination and optimizing based on the three layers framework of distribution center, region distribution center and retail shop. The simulation result shows that the model and algorithm is indeed effective to solve the supply problems in multicommodity or multi-shop.