To solve implant's looseness and subsidence, and to adapt for the requirement of custom-made hip endoprostheses' rapid automatic design and manufacture, a new method is presented for constituting the anisotropic and inhomogeneous model of proximal femur based on CT, CAD technology and finite element analysis during design of custom-made hip endoprostheses, Raw CT image data, 3-D modeling and finite element software is utilized to set up 3-D finite element model of proximal femur. The model is provided with anisotropy and inhomogeneity by self-developed specific software. The near true proximal femur model is structured and good biomechanics condition is provided for optimize design of custom-made hip endoprostheses. For simulating and analysing of proximal femur's structrue and material mechanics property, and determining stress ,strain and response after-operation under the action of physiological load more exactly, and supplying design of custom-made hip endoprostheses with data, the method can provide biomechanics condition for optimize design of custom-made hip prostheses.