By in troducing the way of the immobilized cell and conparing the carriers, this paper presented the advances in immobilized microorganism and its applications of wastewater treatment are presented. It is believed that immobilized microorganism treatment is a more effective mediod than general biological method. The paper discusses its application in treating heavy metal wastewater, organic wastewater, hydroxybenzen wastewate, and nitrogen wastewater,et ac. And the research indicates the advances and the problems of immobilized microorganism.