In-beaker flocculation experiments are performed on the treatment of thick organic wastewater from sodium glutamate production. The effects of different flocculantand its dosage, pH value, and the effects of the composition between the inorganic polymer flocculants and the organic polymer flocculants are investigated.The best flocculation effect is achieved by adopting an inorganic polymeric flocculant PFSS(self-made). Under the condition of pH value within (7.5) to 8.5, the optimum dosage of PFSS is 20 mg/L, the COD_(cr)removal ratio was 68%, and the turbidity removal efficiency was over 89.7%. While, the organic polymer flocculants can synergistic coagulation effects when it is compounded with PFSS. The results demonstrate that the application of such flocculation technology to the pretreatment of thick effluent from sodium glutamate production is effective and economic.