Effects of hemorheology on pathogenesis and key role endotoxin playing in endotoxaemia as well as Multiple Organ Dysfunction Syndrome (MODS) have been discussed. The close relationship between endotoxin in blood and hemorheological characteristics has been discovered through discovering hemorheology in endotoxamia. There is no effctive medication for endotoxaemia in clinical application. Hemoperfusion with Polymyixin B immobilized polystyrene microbeads can remove endotoxin of blood and improve hemorheology. Thus, polymyxin B immobilized polystyrene microbeads have a bright future in emergency trearment.