With the rapid development in logic circuit,the effect of transmission line in PCB becomes a confined factor.In the design of high-speed PCB,the factors which affect the integrity of signal can be found by computerized simulation of the transmission line,simultaneously the signal quality could be optimized.The capacitance matrices of transmission line in high-speed PCB have been computed with this method that is the total charge Green's functions with method of matrix,then the time-domain model is built.Connected to IBIS model of the I/O buffer these models can be used in computerized simulation of the transmission line.The result of simulation is equal with the result produced by EDA software-Specctraquest of cadence Co.and the efficiency of simulation is advanced.