Focusing on the varying status of the enterprise actual sales mode during the informationization of sales management, the authors put forward the virtual filiale mode for the development of the sales management information system, which is very helpful for increasing the flexibility and versatility of the sales management information system and satisfying the demands of sales management informationization of the enterprise sales mode of which is various. The authors also study the characteristics, function cell and application mechanism, at the same time this mode is applied in the practical development of the sales management information system.