This paper introduces the portable data acquisition system based on MSP430F149 micro controller. In this system, PGA chip MCP6s28 is applied to reduce the quantity of devices and power dissipation of the system. Real-time transmission is implemented by the wireless data transceiver. Large memory capacity make it convenient for field operation. The system realizes the menu management by using the graphic LCD. It has the features of small size,low power dissipation, high conversion rate.Therefore,the system is suitable to use dry battery and work in confined space.