Due to lack of estimation during initial stage of traditional physical design process for industry product, the efficiency of conduct development is low with high cost. A basic framework of twisted blade virtual design is set up based on the theory and method of product virtual design, and aiming at the thermodynamic process of middle or lower stage of steam turbine. The molding rule of twisted blade is found by thermodynamic computation program. The study of blade virtual design is carried through from 3-dimensional modeling to simulation test. The combination of thermal power theory, computer simulation technology and CAD system forms a kind of design method with the superiority such as high efficiency, low cost and good decidability is represented in the virtual design of turbine blade.