The importance of human-information system interaction efficiency within enterprise informationization environment is analyzed.The intension of human-information system interaction efficiency is studied from definition,characteristic and evaluation.According to different properties,the influencing factors of human-information system interaction efficiency are divided into five kinds,including human factor,information system factor,management factor,environment factor,and technology factor.On this basis,the concept model of human-information system interaction efficiency is brought forward,and mechanisms of influencing factors to human-information system interaction efficiency are discussed in the model.The analysis indicates: As the core parts of the model,human factor and information system factor determine interaction efficiency directly.Management factor restricts or supports efficiency of human and information system.Environment factor and technology factor bring indirect influence to interaction efficiency by restricting or supporting human factor and information system factor.